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<p>In Nederland heb je slechts kleine gele stickertjes op het
medicatiedoosje "kan de rijvaardigheid beïnvloeden"... <br>
</p>
<p>In de VS heb je Black Box Warnings:</p>
<p><a moz-do-not-send="true"
href="https://www.google.com/search?q=fda+black+box+warning&tbm=isch">https://www.google.com/search?q=fda+black+box+warning&tbm=isch</a></p>
<p><br>
</p>
<p><img alt="Afbeelding" draggable="true"
src="https://pbs.twimg.com/media/FwH_yqvX0AQrnQT?format=png&name=small"
class="css-9pa8cd"></p>
<p><br>
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<h3 class="wp-block-heading"
id="block-0df3f70d-d655-49f8-b66f-4067808a1f3c"><strong>List of
Black Box Warnings</strong>!</h3>
<figure class="wp-block-table nostyle">
<table>
<thead><tr>
<th><strong>Drug/Drug Class</strong></th>
<th><strong>Examples</strong></th>
<th><strong>Warning</strong></th>
</tr>
</thead><tbody>
<tr>
<td><strong>Antipsychotics</strong></td>
<td>Quetiapine<br>
Haloperidol<br>
Olanzapine<br>
Risperidone</td>
<td>Increased mortality in older patients with
dementia-related psychosis.</td>
</tr>
<tr>
<td><strong>Atypical antipsychotic</strong></td>
<td>Clozapine</td>
<td>Agranulocytosis</td>
</tr>
<tr>
<td><strong>Fluoroquinolones</strong></td>
<td>Ciprofloxacin<br>
Moxifloxacin<br>
Levofloxacin<br>
</td>
<td>Increased risk of tendon rupture/damage. This risk is
heightened in elderly patients, and in those who take
corticosteroids.</td>
</tr>
<tr>
<td><strong>SSRIs</strong></td>
<td>Paroxetine<br>
Fluoxetine<br>
Sertraline<br>
Fluvoxamine<br>
Escitalopram</td>
<td>Increased risk of suicidal ideation, particularly in
younger patients. Same risk with most other
antidepressants, such as SNRIs.</td>
</tr>
<tr>
<td><strong>Antiarrhythmic</strong></td>
<td>Amiodarone</td>
<td>Increased risk of pulmonary toxicity, hepatotoxicity,
and heart block.</td>
</tr>
<tr>
<td><strong>Antimalarials</strong></td>
<td>Mefloquine</td>
<td>Increased risk of neuropsychiatric effects such as
anxiety, depression, seizures, hallucinations, and loss of
balance.</td>
</tr>
<tr>
<td><strong>Monoclonal antibody</strong></td>
<td>Natalizumab</td>
<td>Increased risk of progressive<br>
multilocal leukoencephalopathy (PML).</td>
</tr>
<tr>
<td><strong>Progestins</strong></td>
<td>Medroxyprogesterone</td>
<td>Reduced bone density, particularly in premenopausal
women. This effect is reversible once the medicine is
discontinued.</td>
</tr>
<tr>
<td><strong>Fatty acids </strong></td>
<td>Valproic acid</td>
<td>Hepatotoxicity<br>
Pancreatitis</td>
</tr>
<tr>
<td><strong>Opioids</strong></td>
<td>Oxycodone<br>
Morphine<br>
Hydrocodone<br>
Fentanyl<br>
</td>
<td>Risk of addiction, misuse, abuse. Life-threatening
respiratory depression. </td>
</tr>
<tr>
<td><strong>Long-acting beta-2</strong> <strong>agonists</strong></td>
<td>Formoterol<br>
Salmeterol</td>
<td>Increased risk of asthma-related death. Should be used
in combination with an inhaled corticosteroid such as
fluticasone or budesonide.</td>
</tr>
<tr>
<td><strong>Sodium blockers</strong></td>
<td>Carbamazepine<br>
Lamotrigine</td>
<td>Life-threatening skin reactions such as Stevens-Johnson
syndrome, DRESS syndrome, and toxic epidermal necrolysis
(TEN).</td>
</tr>
<tr>
<td><strong>Direct thrombin inhibitor</strong></td>
<td>Dabigatran</td>
<td>Blood clot formation that can cause permanent paralysis
if the drug is injected into the patient’s spinal/epidural
area; or have a spinal puncture.</td>
</tr>
<tr>
<td><strong>Xanthine oxidase inhibitor</strong></td>
<td>Febuxostat</td>
<td>Increased risk of serious cardiovascular events.</td>
</tr>
<tr>
<td><strong>Tyrosine kinase inhibitors</strong></td>
<td>Nilotinib</td>
<td>Increased risk of QT prolongation.</td>
</tr>
<tr>
<td><strong>Thiazolidinediones</strong></td>
<td>Pioglitazone</td>
<td>Increased risk of heart failure.</td>
</tr>
<tr>
<td><strong>Tetracyclines</strong></td>
<td>Tigecycline</td>
<td>Increased risk of death when given IV for serious
infections such as ventilator-associated pneumonia and
complicated intra-abdominal infections.</td>
</tr>
<tr>
<td><strong>IBS medicine</strong></td>
<td>Linaclotide</td>
<td>Increased risk of serious dehydration in children under
6-years. Linaclotide should be avoided in 6-18 years, too.</td>
</tr>
<tr>
<td><strong>Tyrosine kinase inhibitor</strong></td>
<td>Cabozantinib</td>
<td>Holes forming in the stomach (GI perforation), as well
as the risk of GI fistulas.</td>
</tr>
</tbody>
</table>
</figure>
<strong></strong>
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