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<address><a class="moz-txt-link-freetext"
href="https://www.geertvandenbossche.org/post/why-the-ongoing-mass-vaccination-experiment-drives-a-rapid-evolutionary-response-of-sars-cov-2">https://www.geertvandenbossche.org/post/why-the-ongoing-mass-vaccination-experiment-drives-a-rapid-evolutionary-response-of-sars-cov-2</a><br>
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<li class="_3py2c"><span title="Jun 21"
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data-hook="time-ago">Jun 21</span></li>
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<li class="_3py2c"><span class="post-metadata__readTime"
title="33 min read" data-hook="time-to-read">33 min read</span></li>
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<h1 class="_2zPFV _3hhFM blog-post-title-font
blog-post-title-color blog-text-color post-title
blog-hover-container-element-color _3DFPj
blog-post-page-title-font" data-hook="post-title"><span
class="post-title__text blog-post-title-font
blog-post-title-color"><span class="blog-post-title-font
blog-post-title-color">Why the ongoing mass vaccination
experiment drives a rapid evolutionary response of
SARS-CoV-2</span></span></h1>
</div>
</div>
<p id="viewer-foo" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"> </span></p>
<p id="viewer-25cme" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><u class="sDZYg">Critical opinion
article</u>: </span></p>
<p id="viewer-23h65" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><em>The naked scientific truth on
why the ongoing mass vaccination experiment drives a rapid
evolutionary response of SARS-CoV-2 </em></span></p>
<div id="viewer-aav4d" class="XzvDs _208Ie _1atvN _2QAo- _25MYV
_2WrB- _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-9tral" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">The ongoing denial by WHO, public
health agencies and governments of science-based evidence on how
to mitigate the already disastrous global and individual
consequences of this pandemic are beyond mind-blowing. Whereas a
number of medical doctors are now doing the utmost to make
highly successful early multidrug treatment broadly accessible,
I am contributing my part on analyzing the epidemiologic and
health consequences of the ongoing mass vaccination campaigns
and sharing - in all transparency - my insights with the broader
public. From the critical opinion article below, it becomes
already obvious that several scientists who are studying the
evolutionary biology and genetic/ molecular epidemiology of this
pandemic know too well that this pandemic is not over at all and
that the global health risk posed by variants is very
substantial. So, why do they keep silent?</span></p>
<p id="viewer-3dqro" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">I realize that the scientific
language is not easily accessible to laymen. I hope the way I
structured the article will, however, help them to grasp the key
message.</span></p>
<p class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB- _1atvN
public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">[...]<br>
</span></p>
<p class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB- _1atvN
public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></p>
<p class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB- _1atvN
public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><br>
</p>
<p id="viewer-2qc0v" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><strong>Summary</strong></span></p>
<p id="viewer-d1o15" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">As<span style="white-space:
normal;"> </span>Sars-CoV-2<span style="white-space: normal;">
</span>entered<span style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>highly<span
style="white-space: normal;"> </span>susceptible<span
style="white-space: normal;"> </span>human<span
style="white-space: normal;"> </span>population,<span
style="white-space: normal;"> </span>it<span
style="white-space: normal;"> </span>has<span
style="white-space: normal;"> </span>initially<span
style="white-space: normal;"> </span>been<span
style="white-space: normal;"> </span>spreading<span
style="white-space: normal;"> </span>rapidly<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>an<span
style="white-space: normal;"> </span>uncontrollable<span
style="white-space: normal;"> </span>way.<span
style="white-space: normal;"> </span>This<span
style="white-space: normal;"> </span>already<span
style="white-space: normal;"> </span>explains<span
style="white-space: normal;"> </span>why<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>has<span
style="white-space: normal;"> </span>been<span
style="white-space: normal;"> </span>evolving<span
style="white-space: normal;"> </span>rather<span
style="white-space: normal;"> </span>slowly<span
style="white-space: normal;"> </span>with<span
style="white-space: normal;"> </span>no<span
style="white-space: normal;"> </span>substantial<span
style="white-space: normal;"> </span>selection<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>fitness-enhancing<span
style="white-space: normal;"> </span>mutations<span
style="white-space: normal;"> </span>occurring<span
style="white-space: normal;"> </span>over<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>first<span
style="white-space: normal;"> </span>10<span
style="white-space: normal;"> </span>months<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>pandemic<span
style="white-space: normal;"> </span>(i.e.,<span
style="white-space: normal;"> </span>between<span
style="white-space: normal;"> </span>December<span
style="white-space: normal;"> </span>2019<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>October<span
style="white-space: normal;"> </span>2020).<span
style="white-space: normal;"> </span>More<span
style="white-space: normal;"> </span>infectious<span
style="white-space: normal;"> </span>‘variants<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>concern’<span
style="white-space: normal;"> </span>(VoCs,<span
style="white-space: normal;"> </span>i.e.,<span
style="white-space: normal;"> </span>alpha<span
style="white-space: normal;"> </span>[B.1.1.7],<span
style="white-space: normal;"> </span>beta<span
style="white-space: normal;"> </span>[B.1.351],<span
style="white-space: normal;"> </span>gamma<span
style="white-space: normal;"> </span>[P.1])<span
style="white-space: normal;"> </span>started<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>appear<span
style="white-space: normal;"> </span>as<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>late<span
style="white-space: normal;"> </span>2020<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>led<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>steep<span
style="white-space: normal;"> </span>increase<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>cases<span
style="white-space: normal;"> </span>worldwide. </span></p>
<div id="viewer-16ici" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-7pq08" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">Molecular<span style="white-space:
normal;"> </span>epidemiologists<span style="white-space:
normal;"> </span>have<span style="white-space: normal;"> </span>observed<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>mutations<span
style="white-space: normal;"> </span>within<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>spike<span
style="white-space: normal;"> </span>(S)<span
style="white-space: normal;"> </span>protein<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>these<span
style="white-space: normal;"> </span>emerging,<span
style="white-space: normal;"> </span>more<span
style="white-space: normal;"> </span>infectious<span
style="white-space: normal;"> </span>lineages<span
style="white-space: normal;"> </span>are<span
style="white-space: normal;"> </span>converging<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>same<span
style="white-space: normal;"> </span>genetic<span
style="white-space: normal;"> </span>sites,<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>phenomenon<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>coincided<span
style="white-space: normal;"> </span>with<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>major<span
style="white-space: normal;"> </span>evolutionary<span
style="white-space: normal;"> </span>shift<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>landscape<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>naturally<span
style="white-space: normal;"> </span>selected<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>mutations<span
style="white-space: normal;"> </span>(1). </span></p>
<div id="viewer-4vcdk" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-kat0" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">Significant<span
style="white-space: normal;"> </span>convergent<span
style="white-space: normal;"> </span>evolution(*)<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>more<span
style="white-space: normal;"> </span>infectious<span
style="white-space: normal;"> </span>circulating<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>not<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>neutral,<span
style="white-space: normal;"> </span>host-independent<span
style="white-space: normal;"> </span>evolutionary<span
style="white-space: normal;"> </span>phenomenon<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>merely<span
style="white-space: normal;"> </span>results<span
style="white-space: normal;"> </span>from<span
style="white-space: normal;"> </span>increased<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>replication<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>transmission<span
style="white-space: normal;"> </span>but<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>strongly<span
style="white-space: normal;"> </span>suggestive<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>natural<span
style="white-space: normal;"> </span>selection<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>adaptation<span
style="white-space: normal;"> </span>following<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>dramatic<span
style="white-space: normal;"> </span>shift<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>host(ile)<span
style="white-space: normal;"> </span>environment<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>virus<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>exposed<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>(1). </span></p>
<div id="viewer-d0n4t" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-av06" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">Molecular<span style="white-space:
normal;"> </span>epidemiologists<span style="white-space:
normal;"> </span>fully<span style="white-space: normal;"> </span>acknowledge<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>pandemic<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>currently<span
style="white-space: normal;"> </span>evolving<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>“<em>could</em><span
style="white-space: normal;"><em> </em></span><em>be</em><span
style="white-space: normal;"><em> </em></span><em>a</em><span
style="white-space: normal;"><em> </em></span><em>considerably</em><span
style="white-space: normal;"><em> </em></span><em>bigger</em><span
style="white-space: normal;"><em> </em></span><em>problem</em><span
style="white-space: normal;"><em> </em></span><em>for</em><span
style="white-space: normal;"><em> </em></span><em>us</em><span
style="white-space: normal;"><em> </em></span><em>than</em><span
style="white-space: normal;"><em> </em></span><em>any</em><span
style="white-space: normal;"><em> </em></span><em>variants</em><span
style="white-space: normal;"><em> </em></span><em>that</em><span
style="white-space: normal;"><em> </em></span><em>we</em><span
style="white-space: normal;"><em> </em></span><em>currently</em><span
style="white-space: normal;"><em> </em></span><em>know</em><span
style="white-space: normal;"><em> </em></span><em>in</em><span
style="white-space: normal;"><em> </em></span><em>that</em><span
style="white-space: normal;"><em> </em></span><em>they</em><span
style="white-space: normal;"><em> </em></span><em>might</em><span
style="white-space: normal;"><em> </em></span><em>have</em><span
style="white-space: normal;"><em> </em></span><em>any</em><span
style="white-space: normal;"><em> </em></span><em>combinations</em><span
style="white-space: normal;"><em> </em></span><em>of</em><span
style="white-space: normal;"><em> </em></span><em>increased</em><span
style="white-space: normal;"><em> </em></span><em>transmissibility,</em><span
style="white-space: normal;"><em> </em></span><em>altered</em><span
style="white-space: normal;"><em> </em></span><em>virulence</em><span
style="white-space: normal;"><em> </em></span><em>and/or</em><span
style="white-space: normal;"><em> </em></span><em>increased</em><span
style="white-space: normal;"><em> </em></span><em>capacity</em><span
style="white-space: normal;"><em> </em></span><em>to</em><span
style="white-space: normal;"><em> </em></span><em>escape</em><span
style="white-space: normal;"><em> </em></span><em>population</em><span
style="white-space: normal;"><em> </em></span><em>immunity</em>”<span
style="white-space: normal;"> </span>(1).<span
style="white-space: normal;"> </span>This<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>say<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>phylogenetics-based<span
style="white-space: normal;"> </span>natural<span
style="white-space: normal;"> </span>selection<span
style="white-space: normal;"> </span>analysis<span
style="white-space: normal;"> </span>on<span
style="white-space: normal;"> </span>circulating<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>lineages<span
style="white-space: normal;"> </span>strongly<span
style="white-space: normal;"> </span>suggests<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>resistant<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>spike<span
style="white-space: normal;"> </span>(S)-based<span
style="white-space: normal;"> </span>Covid-19<span
style="white-space: normal;"> </span>vaccines<span
style="white-space: normal;"> </span>are<span
style="white-space: normal;"> </span>currently<span
style="white-space: normal;"> </span>expanding<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>prevalence<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>highly<span
style="white-space: normal;"> </span>suspicious<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>causing<span
style="white-space: normal;"> </span>future<span
style="white-space: normal;"> </span>epidemic<span
style="white-space: normal;"> </span>surges<span
style="white-space: normal;"> </span>globally.</span></p>
<div id="viewer-9no55" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-2lupg" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">Deployment<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>current<span
style="white-space: normal;"> </span>Covid-19<span
style="white-space: normal;"> </span>vaccines<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>mass<span
style="white-space: normal;"> </span>vaccination<span
style="white-space: normal;"> </span>campaigns<span
style="white-space: normal;"> </span>combined<span
style="white-space: normal;"> </span>with<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>ongoing<span
style="white-space: normal;"> </span>widespread<span
style="white-space: normal;"> </span>circulation<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>can<span
style="white-space: normal;"> </span>only<span
style="white-space: normal;"> </span>increase<span
style="white-space: normal;"> </span>immune<span
style="white-space: normal;"> </span>selective<span
style="white-space: normal;"> </span>pressure<span
style="white-space: normal;"> </span>on<span
style="white-space: normal;"> </span>Sars-CoV-2<span
style="white-space: normal;"> </span>spike<span
style="white-space: normal;"> </span>protein<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>hence,<span
style="white-space: normal;"> </span>further<span
style="white-space: normal;"> </span>drive<span
style="white-space: normal;"> </span>its<span
style="white-space: normal;"> </span>adaptive<span
style="white-space: normal;"> </span>evolution<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>circumvent<span
style="white-space: normal;"> </span>vaccine-induced<span
style="white-space: normal;"> </span>humoral<span
style="white-space: normal;"> </span>immunity.<span
style="white-space: normal;"> </span>In<span
style="white-space: normal;"> </span>this<span
style="white-space: normal;"> </span>regard,<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>expectation<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>an<span
style="white-space: normal;"> </span>increasing<span
style="white-space: normal;"> </span>number<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>vaccinologists<span
style="white-space: normal;"> </span>matches<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>current<span
style="white-space: normal;"> </span>observation<span
style="white-space: normal;"> </span>made<span
style="white-space: normal;"> </span>by<span
style="white-space: normal;"> </span>genomic<span
style="white-space: normal;"> </span>epidemiologists<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>that<span
style="white-space: normal;"> </span>S<span
style="white-space: normal;"> </span>protein-directed<span
style="white-space: normal;"> </span>immune<span
style="white-space: normal;"> </span>escape<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>are<span
style="white-space: normal;"> </span>highly<span
style="white-space: normal;"> </span>likely<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>further<span
style="white-space: normal;"> </span>spread<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>expedite<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>occurrence<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>resistance<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>currently<span
style="white-space: normal;"> </span>deployed<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>future<span
style="white-space: normal;"> </span>(so-called<span
style="white-space: normal;"> </span>‘2nd<span
style="white-space: normal;"> </span>generation’)<span
style="white-space: normal;"> </span>Covid-19<span
style="white-space: normal;"> </span>vaccines. </span></p>
<div id="viewer-5uh0i" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-2s78u" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">To<span style="white-space:
normal;"> </span>monitor<span style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>circulation<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>hazardous<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>in<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>population<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>be<span
style="white-space: normal;"> </span>able<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>provide<span
style="white-space: normal;"> </span>unequivocal<span
style="white-space: normal;"> </span>proof<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>immune<span
style="white-space: normal;"> </span>selection<span
style="white-space: normal;"> </span>pressure<span
style="white-space: normal;"> </span>exerted<span
style="white-space: normal;"> </span>by<span
style="white-space: normal;"> </span>mass<span
style="white-space: normal;"> </span>vaccination<span
style="white-space: normal;"> </span>campaigns<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>harmful<span
style="white-space: normal;"> </span>consequences<span
style="white-space: normal;"> </span>thereof,<span
style="white-space: normal;"> </span>there<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>an<span
style="white-space: normal;"> </span>urgent<span
style="white-space: normal;"> </span>need<span
style="white-space: normal;"> </span>for<span
style="white-space: normal;"> </span>conducting<span
style="white-space: normal;"> </span>representative<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>sampling<span
style="white-space: normal;"> </span>on<span
style="white-space: normal;"> </span>vaccinees,<span
style="white-space: normal;"> </span>including<span
style="white-space: normal;"> </span>those<span
style="white-space: normal;"> </span>who<span
style="white-space: normal;"> </span>are<span
style="white-space: normal;"> </span>healthy<span
style="white-space: normal;"> </span>or<span
style="white-space: normal;"> </span>only<span
style="white-space: normal;"> </span>subject<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>mild<span
style="white-space: normal;"> </span>disease,<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>genetically<span
style="white-space: normal;"> </span>characterize<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>variants<span
style="white-space: normal;"> </span>they<span
style="white-space: normal;"> </span>shed<span
style="white-space: normal;"> </span>upon<span
style="white-space: normal;"> </span>exposure<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>Sars-CoV-2. </span></p>
<div id="viewer-2koco" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-96mdq" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><u><span class="vkIF2
public-DraftStyleDefault-ltr">Conducting<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>mass<span
style="white-space: normal;"> </span>vaccination<span
style="white-space: normal;"> </span>experiment<span
style="white-space: normal;"> </span>at<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>global<span
style="white-space: normal;"> </span>scale<span
style="white-space: normal;"> </span>without<span
style="white-space: normal;"> </span>understanding<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>mechanisms<span
style="white-space: normal;"> </span>underlying<span
style="white-space: normal;"> </span>viral<span
style="white-space: normal;"> </span>escape<span
style="white-space: normal;"> </span>from<span
style="white-space: normal;"> </span>vaccine-mediated<span
style="white-space: normal;"> </span>selection<span
style="white-space: normal;"> </span>pressure<span
style="white-space: normal;"> </span>is<span
style="white-space: normal;"> </span>not<span
style="white-space: normal;"> </span>only<span
style="white-space: normal;"> </span>a<span
style="white-space: normal;"> </span>colossal<span
style="white-space: normal;"> </span>scientific<span
style="white-space: normal;"> </span>blunder<span
style="white-space: normal;"> </span>but,<span
style="white-space: normal;"> </span>first<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>foremost,<span
style="white-space: normal;"> </span>completely<span
style="white-space: normal;"> </span>irresponsible<span
style="white-space: normal;"> </span>from<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>perspective<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>individual<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>public<span
style="white-space: normal;"> </span>health<span
style="white-space: normal;"> </span>ethics. </span></u></p>
<p id="viewer-ea6k0" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">In<span style="white-space:
normal;"> </span>the<span style="white-space: normal;"> </span>absence<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>vaccines<span
style="white-space: normal;"> </span>capable<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>inducing<span
style="white-space: normal;"> </span>sterilizing<span
style="white-space: normal;"> </span>immunity,<span
style="white-space: normal;"> </span>early<span
style="white-space: normal;"> </span>multidrug<span
style="white-space: normal;"> </span>treatment<span
style="white-space: normal;"> </span>as<span
style="white-space: normal;"> </span>proposed<span
style="white-space: normal;"> </span>by<span
style="white-space: normal;"> </span>Prof.<span
style="white-space: normal;"> </span>Dr.<span
style="white-space: normal;"> </span>P.<span
style="white-space: normal;"> </span>McCullough<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>others<span
style="white-space: normal;"> </span>(<a
href="https://pubmed.ncbi.nlm.nih.gov/33387997/"
target="_blank" rel="noopener noreferrer" class="_2qJYG
_2E8wo"><u class="sDZYg">https://pubmed.ncbi.nlm.nih.gov/33387997/</u></a><u
class="sDZYg">),</u><span style="white-space: normal;"> </span>together<span
style="white-space: normal;"> </span>with<span
style="white-space: normal;"> </span>global<span
style="white-space: normal;"> </span>chemoprophylaxis<span
style="white-space: normal;"> </span>using<span
style="white-space: normal;"> </span>highly<span
style="white-space: normal;"> </span>efficient<span
style="white-space: normal;"> </span>antiviral<span
style="white-space: normal;"> </span>drugs,<span
style="white-space: normal;"> </span>will<span
style="white-space: normal;"> </span>be<span
style="white-space: normal;"> </span>key<span
style="white-space: normal;"> </span>to<span
style="white-space: normal;"> </span>save<span
style="white-space: normal;"> </span>lives,<span
style="white-space: normal;"> </span>reduce<span
style="white-space: normal;"> </span>the<span
style="white-space: normal;"> </span>hospitalization<span
style="white-space: normal;"> </span>burden<span
style="white-space: normal;"> </span>and<span
style="white-space: normal;"> </span>dramatically<span
style="white-space: normal;"> </span>diminish<span
style="white-space: normal;"> </span>transmission<span
style="white-space: normal;"> </span>of<span
style="white-space: normal;"> </span>highly<span
style="white-space: normal;"> </span>infectious<span
style="white-space: normal;"> </span>or<span
style="white-space: normal;"> </span>neutralizing<span
style="white-space: normal;"> </span>antibody<span
style="white-space: normal;"> </span>(nAb)-resistant<span
style="white-space: normal;"> </span>escape<span
style="white-space: normal;"> </span>variants. </span></p>
<div id="viewer-7ecd2" class="XzvDs _208Ie _1atvN _2QAo- _1iXso
_3_La3 _1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"><br>
</span></div>
<p id="viewer-u4th" class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB-
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr">(*) Convergent evolution relates
to the independent occurrence of one or more mutations that are
shared in common across several viral variants</span></p>
<p id="viewer-602os" class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3
_1atvN public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"> </span><br>
</p>
<p class="XzvDs _208Ie _1atvN _2QAo- _1iXso _3_La3 _1atvN
public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr">[...]<br>
</p>
<p class="XzvDs _208Ie _1atvN _2QAo- _25MYV _2WrB- _1atvN
public-DraftStyleDefault-block-depth0
public-DraftStyleDefault-text-ltr"><span class="vkIF2
public-DraftStyleDefault-ltr"></span></p>
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