[D66] Zou dit waar zijn? Doorbraak ?

Erik van den Muijzenberg muijz at dds.nl
Fri Dec 16 23:08:38 CET 2011


Henkie, hou toch eens op met je infantiele gespam!
Dit is een *discussie*lijst. Over zaken die iets te maken hebben met  
*D66*.

Dat er een nieuw geneesmiddel is ontdekt is mooi, en je kunt daar ook
gerust over schrijven, op je eigen blog. Maar niet hier s.v.p.

Vriendelijk dank voor je begrip en medewerking.
Erik vdMb


On Dec 16, 2011, at 8:18 PM, Henk Elegeert wrote:

>
> Zou dit waar zijn? Doorbraak ?
>
> A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's  
> Disease
>
> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027865
>
> "..
>
> Abstract
> Currently, the major drug discovery paradigm for neurodegenerative  
> diseases is based upon high affinity ligands for single
> disease-specific targets. For Alzheimer’s disease (AD), the focus is  
> the amyloid beta peptide (Aß) that mediates familial
> Alzheimer’s disease pathology. However, given that age is the  
> greatest risk factor for AD, we explored an alternative drug
> discovery scheme that is based upon efficacy in multiple cell  
> culture models of age-associated pathologies rather than
> exclusively amyloid metabolism. Using this approach, we identified  
> an exceptionally potent, orally active, neurotrophic
> molecule that facilitates memory in normal rodents, and prevents the  
> loss of synaptic proteins and cognitive decline in a
> transgenic AD mouse model.
>
> ..
>
> "
>
> Nieuw medicijn Alzheimer een halt toeroept ?
>
> Henk Elegeert
>
> PLoS ONE is run as a partnership between its in-house PLoS staff and  
> international Advisory and Editorial Boards, ensuring fast, fair,  
> and professional peer review.
>
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