[D66] Zou dit waar zijn? Doorbraak ?

[Henk Elegeert]

Zou dit waar zijn? Doorbraak ?

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027865

"..

Abstract
Currently, the major drug discovery paradigm for neurodegenerative diseases
is based upon high affinity ligands for single
disease-specific targets. For Alzheimer’s disease (AD), the focus is the
amyloid beta peptide (Aß) that mediates familial
Alzheimer’s disease pathology. However, given that age is the greatest risk
factor for AD, we explored an alternative drug
discovery scheme that is based upon efficacy in multiple cell culture
models of age-associated pathologies rather than
exclusively amyloid metabolism. Using this approach, we identified an
exceptionally potent, orally active, neurotrophic
molecule that facilitates memory in normal rodents, and prevents the loss
of synaptic proteins and cognitive decline in a
transgenic AD mouse model.

..

"

Nieuw medicijn Alzheimer een halt toeroept ?

Henk Elegeert

*PLoS ONE* is run as a partnership between its in-house PLoS staff and
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